It has been known for quite some time that the gut microbiome, the collection of microorganisms in the gastrointestinal tract, can influence mood and #skinhealth. Since 5-HTP produces such good results in some patients who experienced depression, researchers looked at the effects of 5-HTP on the gut microbiome in mice.
What they discovered is that one of the significant anti-depressant effects of 5-HTP is restructuring the gut microbiome and improving the “microbiota-gut-brain axis.”
5-HTP also increased the concentrations of short-chain fatty acids like butyrate and brain-derived chemicals associated with improved brain function and mood. These results provide even more support for the antidepressant effects of 5-HTP. When taking a 5-HTP supplement, always consult with your physician prior to use to discuss your unique health situation. Use an “enteric-coated” product or a chewable tablet to prevent stomach upset. And if you want to take advantage of 5-HTP’s appetite suppressing effect, take it 20 minutes before meals. Source: Wu L, Ran L, Wu Y, Liang M, Zeng J, Ke F, Wang F, Yang J, Lao X, Liu L, Wang Q, Gao X. Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression. Front Microbiol. 2022 Apr 28;13:864571. doi: 10.3389/fmicb.2022.864571. PMID: 35572711; PMCID: PMC9096562.
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